The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. Is Monday Night Football one of the Week 6 NFL lines that you should avoid? Or will Josh Allen lead his team to a fifth straight win? Whether you're thinking of making Week 6 NFL picks on these games or others, be sure to see the Week 6 NFL predictions from the proven computer model at SportsLine. Tennessee bounced back from a loss to the Jets with a 37-19 win at Jacksonville and now faces one of the larger NFL spreads of the week. The Bills will have to avoid a letdown following their impressive win at Kansas City last Sunday.

Caesars Sportsbook lists Buffalo as a 5.5-point road favorite in the latest Week 6 NFL odds. The Week 6 NFL schedule will conclude on Monday Night Football when Tennessee hosts Buffalo.

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